K. Budipramana, K.R. Wirasutisna, M.W. Wartono, Y.B. Pramana, S. Sukrasno, T.A. Yuniarta
Dipeptidyl peptidase-4 (DPP-4) inhibitors are diabetes mellitus drugs that inhibit the metabolism of glucagon-like peptide-1 (GLP-1) from the DPP-4 enzyme thus prolong the half-life of GLP-1. This review provides an overview of DPP-4 inhibitors from triterpenes and steroids and some related compounds from in silico prediction, in vitro, and in vivo studies. The knowledge of the heterogeneity of DPP-4 inhibitors structure from synthetic drugs as well as natural sources will assist to design more potential DPP-4 inhibitors, yet it is needed to be evaluated clinically. Hopefully, the scientific combination among molecular modelling and experimental studies perspectives will generate DPP-4 inhibitors with the desired outcome. © 2021, Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma. All rights reserved.
Pharmaceutical Biology Research Group, School of Pharmacy, Bandung Institute of Technology, Bandung, 40132, Indonesia; Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Surabaya, Surabaya, 60293, Indonesia; Chemistry Department, Faculty of Mathematics and Natural Sciences, Sebelas Maret University, Surakarta, 57126, Indonesia; Industrial Engineering Department, Faculty of Industrial Technology, University of PGRI Adi Buana, Surabaya, 60234, Indonesia; Department of Pharmacy, Sumatera Institute of Technology, South Lampung, Sumatera, 35365, Indonesia; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Surabaya, Jalan Raya Kali Rungkut, Surabaya, Indonesia
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